Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

Targeting and invading double-stranded DNA with synthetic oligonucleotides under physiological conditions remain a challenge. Bis-locked nucleic acids (bisLNAs) are clamp-forming oligonucleotides able to invade into supercoiled DNA via combined Hoogsteen and Watson–Crick binding. To improve the bisL...

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Udgivet i:Nucleic Acids Res
Main Authors: Geny, Sylvain, Moreno, Pedro M. D., Krzywkowski, Tomasz, Gissberg, Olof, Andersen, Nicolai K., Isse, Abdirisaq J., El-Madani, Amro M., Lou, Chenguang, Pabon, Y. Vladimir, Anderson, Brooke A., Zaghloul, Eman M., Zain, Rula, Hrdlicka, Patrick J., Jørgensen, Per T., Nilsson, Mats, Lundin, Karin E., Pedersen, Erik B., Wengel, Jesper, Smith, C. I. Edvard
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Chemical Biology and Nucleic Acid Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797291/
https://ncbi.nlm.nih.gov/pubmed/26857548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw021
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