The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

Locked nucleic acid (LNA) oligonucleotides bind DNA target sequences forming Watson-Crick and Hoogsteen base pairs, and are therefore of interest for medical applications. To be biologically active, such an oligonucleotide has to efficiently bind the target sequence. Here we used molecular dynamics...

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Publicat a:PLoS One
Autors principals: Xu, You, Gissberg, Olof, Pabon-Martinez, Y. Vladimir, Wengel, Jesper, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula, Nilsson, Lennart, Villa, Alessandra
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372149/
https://ncbi.nlm.nih.gov/pubmed/30753192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211651
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