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The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study
Locked nucleic acid (LNA) oligonucleotides bind DNA target sequences forming Watson-Crick and Hoogsteen base pairs, and are therefore of interest for medical applications. To be biologically active, such an oligonucleotide has to efficiently bind the target sequence. Here we used molecular dynamics...
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| Publié dans: | PLoS One |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6372149/ https://ncbi.nlm.nih.gov/pubmed/30753192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211651 |
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