The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study

Locked nucleic acid (LNA) oligonucleotides bind DNA target sequences forming Watson-Crick and Hoogsteen base pairs, and are therefore of interest for medical applications. To be biologically active, such an oligonucleotide has to efficiently bind the target sequence. Here we used molecular dynamics...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Xu, You, Gissberg, Olof, Pabon-Martinez, Y. Vladimir, Wengel, Jesper, Lundin, Karin E., Smith, C. I. Edvard, Zain, Rula, Nilsson, Lennart, Villa, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372149/
https://ncbi.nlm.nih.gov/pubmed/30753192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211651
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