Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

Targeting and invading double-stranded DNA with synthetic oligonucleotides under physiological conditions remain a challenge. Bis-locked nucleic acids (bisLNAs) are clamp-forming oligonucleotides able to invade into supercoiled DNA via combined Hoogsteen and Watson–Crick binding. To improve the bisL...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Geny, Sylvain, Moreno, Pedro M. D., Krzywkowski, Tomasz, Gissberg, Olof, Andersen, Nicolai K., Isse, Abdirisaq J., El-Madani, Amro M., Lou, Chenguang, Pabon, Y. Vladimir, Anderson, Brooke A., Zaghloul, Eman M., Zain, Rula, Hrdlicka, Patrick J., Jørgensen, Per T., Nilsson, Mats, Lundin, Karin E., Pedersen, Erik B., Wengel, Jesper, Smith, C. I. Edvard
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797291/
https://ncbi.nlm.nih.gov/pubmed/26857548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw021
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