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Functionalized 2′-Amino-α-L-LNA - Directed Positioning of Intercalators for DNA Targeting

Chemically modified oligonucleotides are increasingly applied in nucleic acid based therapeutics and diagnostics. LNA (Locked Nucleic Acid) and its diastereomer α-L-LNA are two promising examples hereof that exhibit increased thermal and enzymatic stability. Herein, the synthesis, biophysical charac...

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Autors principals: Kumar, T. Santhosh, Madsen, Andreas S., Østergaard, Michael E., Sau, Sujay P., Wengel, Jesper, Hrdlicka, Patrick J.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853939/
https://ncbi.nlm.nih.gov/pubmed/19108636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo802037v
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