HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity

Huntington's disease (HD) is a fatal neurodegenerative disease, caused by expansion of polyglutamine repeats in the Huntingtin gene, with longer expansions leading to earlier ages of onset. The HD iPSC Consortium has recently reported a new in vitro model of HD based on the generation of induce...

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Publicat a:Hum Mol Genet
Autors principals: Mattis, Virginia B., Tom, Colton, Akimov, Sergey, Saeedian, Jasmine, Østergaard, Michael E., Southwell, Amber L., Doty, Crystal N., Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Arjomand, Jamshid, Hayden, Michael R., Ross, Christopher A., Svendsen, Clive N.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424959/
https://ncbi.nlm.nih.gov/pubmed/25740845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv080
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