Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development

Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN have mostly utilized patient fibroblasts and...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Fuller, Heidi R., Mandefro, Berhan, Shirran, Sally L., Gross, Andrew R., Kaus, Anjoscha S., Botting, Catherine H., Morris, Glenn E., Sareen, Dhruv
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707261/
https://ncbi.nlm.nih.gov/pubmed/26793058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00506
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