Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses

The hypothalamus contains neurons that integrate hunger and satiety endocrine signals from the periphery and are implicated in the pathophysiology of obesity. The limited availability of human hypothalamic neurons hampers our understanding of obesity disease mechanisms. To address this, we generated...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Rajamani, Uthra, Gross, Andrew R., Hjelm, Brooke E., Sequeira, Adolfo, Vawter, Marquis P., Tang, Jie, Gangalapudi, Vineela, Wang, Yizhou, Andres, Allen M., Gottlieb, Roberta A., Sareen, Dhruv
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398951/
https://ncbi.nlm.nih.gov/pubmed/29681516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.03.009
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