Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses

The hypothalamus contains neurons that integrate hunger and satiety endocrine signals from the periphery and are implicated in the pathophysiology of obesity. The limited availability of human hypothalamic neurons hampers our understanding of obesity disease mechanisms. To address this, we generated...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Stem Cell
Prif Awduron: Rajamani, Uthra, Gross, Andrew R., Hjelm, Brooke E., Sequeira, Adolfo, Vawter, Marquis P., Tang, Jie, Gangalapudi, Vineela, Wang, Yizhou, Andres, Allen M., Gottlieb, Roberta A., Sareen, Dhruv
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398951/
https://ncbi.nlm.nih.gov/pubmed/29681516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.03.009
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