Mitochondrial Dysregulation and Impaired Autophagy in iPSC-Derived Dopaminergic Neurons of Multiple System Atrophy

Multiple system atrophy (MSA) is a progressive neurodegenerative disease that affects several areas of the CNS, whose pathogenesis is still widely unclear and for which an effective treatment is lacking. We have generated induced pluripotent stem cell-derived dopaminergic neurons from four MSA patie...

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Vydáno v:Stem Cell Reports
Hlavní autoři: Monzio Compagnoni, Giacomo, Kleiner, Giulio, Samarani, Maura, Aureli, Massimo, Faustini, Gaia, Bellucci, Arianna, Ronchi, Dario, Bordoni, Andreina, Garbellini, Manuela, Salani, Sabrina, Fortunato, Francesco, Frattini, Emanuele, Abati, Elena, Bergamini, Christian, Fato, Romana, Tabano, Silvia, Miozzo, Monica, Serratto, Giulia, Passafaro, Maria, Deleidi, Michela, Silipigni, Rosamaria, Nizzardo, Monica, Bresolin, Nereo, Comi, Giacomo P., Corti, Stefania, Quinzii, Catarina M., Di Fonzo, Alessio
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234905/
https://ncbi.nlm.nih.gov/pubmed/30344007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.09.007
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