Mitochondrial Dysregulation and Impaired Autophagy in iPSC-Derived Dopaminergic Neurons of Multiple System Atrophy

Multiple system atrophy (MSA) is a progressive neurodegenerative disease that affects several areas of the CNS, whose pathogenesis is still widely unclear and for which an effective treatment is lacking. We have generated induced pluripotent stem cell-derived dopaminergic neurons from four MSA patie...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Monzio Compagnoni, Giacomo, Kleiner, Giulio, Samarani, Maura, Aureli, Massimo, Faustini, Gaia, Bellucci, Arianna, Ronchi, Dario, Bordoni, Andreina, Garbellini, Manuela, Salani, Sabrina, Fortunato, Francesco, Frattini, Emanuele, Abati, Elena, Bergamini, Christian, Fato, Romana, Tabano, Silvia, Miozzo, Monica, Serratto, Giulia, Passafaro, Maria, Deleidi, Michela, Silipigni, Rosamaria, Nizzardo, Monica, Bresolin, Nereo, Comi, Giacomo P., Corti, Stefania, Quinzii, Catarina M., Di Fonzo, Alessio
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234905/
https://ncbi.nlm.nih.gov/pubmed/30344007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.09.007
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