Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development

Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN have mostly utilized patient fibroblasts and...

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Pubblicato in:Front Cell Neurosci
Autori principali: Fuller, Heidi R., Mandefro, Berhan, Shirran, Sally L., Gross, Andrew R., Kaus, Anjoscha S., Botting, Catherine H., Morris, Glenn E., Sareen, Dhruv
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2016
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707261/
https://ncbi.nlm.nih.gov/pubmed/26793058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00506
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