Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes

di Tanowitz, Michael, Hettrick, Lisa, Revenko, Alexey, Kinberger, Garth A., Prakash, Thazha P., Seth, Punit P.
Pubblicato in Nucleic Acids Res (2017)

S-Acyl-2-Thioethyl: A Convenient Base-Labile Protecting Group for the Synthesis of siRNAs Containing 5′-Vinylphosphonate

di Nikan, Mehran, Li, Wenyu, Kinberger, Garth A., Seth, Punit P., Swayze, Eric E., Prakash, Thazha P.
Pubblicato in Molecules (2019)

Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2′-modifications and enhances antisense activity

di Liang, Xue-Hai, Shen, Wen, Sun, Hong, Kinberger, Garth A., Prakash, Thazha P., Nichols, Joshua G., Crooke, Stanley T.
Pubblicato in Nucleic Acids Res (2016)

Structural analysis of human Argonaute-2 bound to a modified siR-NA guide

di Schirle, Nicole T., Kinberger, Garth A., Murray, Heather F., Lima, Walt F., Prakash, Thazha P., MacRae, Ian J.
Pubblicato in J Am Chem Soc (2016)

Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

di Schmidt, Karsten, Prakash, Thazha P., Donner, Aaron J., Kinberger, Garth A., Gaus, Hans J., Low, Audrey, Østergaard, Michael E., Bell, Melanie, Swayze, Eric E., Seth, Punit P.
Pubblicato in Nucleic Acids Res (2017)

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity

di Prakash, Thazha P., Lima, Walt F., Murray, Heather M., Li, Wenyu, Kinberger, Garth A., Chappell, Alfred E., Gaus, Hans, Seth, Punit P., Bhat, Balkrishen, Crooke, Stanley T., Swayze, Eric E.
Pubblicato in Nucleic Acids Res (2015)

Identification of metabolically stable 5΄-phosphate analogs that support single-stranded siRNA activity

di Prakash, Thazha P., Lima, Walt F., Murray, Heather M., Li, Wenyu, Kinberger, Garth A., Chappell, Alfred E., Gaus, Hans, Seth, Punit P., Bhat, Balkrishen, Crooke, Stanley T., Swayze, Eric E.
Pubblicato in Nucleic Acids Res (2017)

Peptide Nucleic Acids Conjugated to Short Basic Peptides Show Improved Pharmacokinetics and Antisense Activity in Adipose Tissue

di Wancewicz, Edward V., Maier, Martin A., Siwkowski, Andrew M., Albertshofer, Klaus, Winger, Theodore M., Berdeja, Andres, Gaus, Hans, Vickers, Timothy A., Bennett, C. Frank, Monia, Brett P., Griffey, Richard H., Nulf, Christopher J., Hu, Jiaxin, Corey, David R., Swayze, Eric E., Kinberger, Garth A.
Pubblicazione 2010

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

di Østergaard, Michael E, Jackson, Michaela, Low, Audrey, E. Chappell, Alfred, G. Lee, Richard, Peralta, Rachel Q, Yu, Jinghua, Kinberger, Garth A, Dan, Amy, Carty, Rick, Tanowitz, Michael, Anderson, Patrick, Kim, Tae-Won, Fradkin, Linda, Mullick, Adam E, Murray, Sue, Rigo, Frank, Prakash, Thazha P, Bennett, C Frank, Swayze, Eric E, Gaus, Hans J, Seth, Punit P
Pubblicato in Nucleic Acids Res (2019)