A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro

gan Raiber, Eun-Ang, Kranaster, Ramon, Lam, Enid, Nikan, Mehran, Balasubramanian, Shankar
Cyhoeddwyd 2012

An Acetylene-Bridged 6,8-Purine Dimer as a Fluorescent Switch-On Probe for Parallel G-Quadruplexes**

gan Nikan, Mehran, Di Antonio, Marco, Abecassis, Keren, McLuckie, Keith, Balasubramanian, Shankar
Cyhoeddwyd 2013

S-Acyl-2-Thioethyl: A Convenient Base-Labile Protecting Group for the Synthesis of siRNAs Containing 5′-Vinylphosphonate

gan Nikan, Mehran, Li, Wenyu, Kinberger, Garth A., Seth, Punit P., Swayze, Eric E., Prakash, Thazha P.
Cyhoeddwyd yn Molecules (2019)

Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles

gan Biscans, Annabelle, Haraszti, Reka A., Echeverria, Dimas, Miller, Rachael, Didiot, Marie-Cecile, Nikan, Mehran, Roux, Loic, Aronin, Neil, Khvorova, Anastasia
Cyhoeddwyd yn Mol Ther (2018)

Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs

gan Osborn, Maire F., Alterman, Julia F., Nikan, Mehran, Cao, Hong, Didiot, Marie C., Hassler, Matthew R., Coles, Andrew H., Khvorova, Anastasia
Cyhoeddwyd yn Nucleic Acids Res (2015)

Small molecule-induced DNA damage identifies alternative DNA structures in human genes

gan Rodriguez, Raphaël, Miller, Kyle M., Forment, Josep V., Bradshaw, Charles R., Nikan, Mehran, Britton, Sébastien, Oelschlaegel, Tobias, Xhemalce, Blerta, Balasubramanian, Shankar, Jackson, Stephen P.
Cyhoeddwyd 2012

Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

gan Nikan, Mehran, Osborn, Maire F, Coles, Andrew H, Godinho, Bruno MDC, Hall, Lauren M, Haraszti, Reka A, Hassler, Matthew R, Echeverria, Dimas, Aronin, Neil, Khvorova, Anastasia
Cyhoeddwyd yn Mol Ther Nucleic Acids (2016)

Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization A...

gan Godinho, Bruno M.D.C., Gilbert, James W., Haraszti, Reka A., Coles, Andrew H., Biscans, Annabelle, Roux, Loic, Nikan, Mehran, Echeverria, Dimas, Hassler, Matthew, Khvorova, Anastasia
Cyhoeddwyd yn Nucleic Acid Ther (2017)

Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable, O-phosphocholine-N-docosahexaenoyl-L-serine siRNA Conjugate in Mouse Brain

gan Nikan, Mehran, Osborn, Maire F., Coles, Andrew H., Biscans, Annabelle, Godinho, Bruno M.D.C., Haraszti, Reka A., Sapp, Ellen, Echeverria, Dimas, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Cyhoeddwyd yn Bioconjug Chem (2017)

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

gan Osborn, Maire F, Coles, Andrew H, Biscans, Annabelle, Haraszti, Reka A, Roux, Loic, Davis, Sarah, Ly, Socheata, Echeverria, Dimas, Hassler, Matthew R, Godinho, Bruno M D C, Nikan, Mehran, Khvorova, Anastasia
Cyhoeddwyd yn Nucleic Acids Res (2019)

Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier

gan Godinho, Bruno M.D.C., Henninger, Nils, Bouley, James, Alterman, Julia F., Haraszti, Reka A., Gilbert, James W., Sapp, Ellen, Coles, Andrew H., Biscans, Annabelle, Nikan, Mehran, Echeverria, Dimas, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Cyhoeddwyd yn Mol Ther (2018)

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

gan Hassler, Matthew R, Turanov, Anton A, Alterman, Julia F, Haraszti, Reka A, Coles, Andrew H, Osborn, Maire F, Echeverria, Dimas, Nikan, Mehran, Salomon, William E, Roux, Loïc, Godinho, Bruno M D C, Davis, Sarah M, Morrissey, David V, Zamore, Phillip D, Karumanchi, S Ananth, Moore, Melissa J, Aronin, Neil, Khvorova, Anastasia
Cyhoeddwyd yn Nucleic Acids Res (2018)