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A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro
SP1 is a ubiquitous transcription factor that is involved in the regulation of various house-keeping genes. It is known that it acts by binding to a double-stranded consensus motif. Here, we have discovered that SP1 binds also to a non-canonical DNA structure, a G-quadruplex, with high affinity. In...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287196/ https://ncbi.nlm.nih.gov/pubmed/22021377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr882 |
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