Health Security Preparedness and Industry Trends

door Crooke, Stanley T.
Gepubliceerd in Health Secur (2015)

Molecular Mechanisms of Antisense Oligonucleotides

door Crooke, Stanley T.
Gepubliceerd in Nucleic Acid Ther (2017)

Clinical pharmacological properties of mipomersen (Kynamro), a second generation antisense inhibitor of apolipoprotein B

door Crooke, Stanley T, Geary, Richard S
Gepubliceerd in 2013

Highly efficient endonucleolytic cleavage of RNA by a Cys(2)His(2) zinc-finger peptide

door Lima, Walt F., Crooke, Stanley T.
Gepubliceerd in 1999

Depletion of key protein components of the RISC pathway impairs pre-ribosomal RNA processing

door Liang, Xue-hai, Crooke, Stanley T.
Gepubliceerd in 2011

siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs

door Vickers, Timothy A., Crooke, Stanley T.
Gepubliceerd in 2012

Antisense Oligonucleotides Capable of Promoting Specific Target mRNA Reduction via Competing RNase H1-Dependent and Independent Mechanisms

door Vickers, Timothy A., Crooke, Stanley T.
Gepubliceerd in 2014

The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA

door Vickers, Timothy A., Crooke, Stanley T.
Gepubliceerd in Nucleic Acids Res (2015)

Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein Interactions

door Vickers, Timothy A., Crooke, Stanley T.
Gepubliceerd in PLoS One (2016)

U1 adaptors result in reduction of multiple pre-mRNA species principally by sequestering U1snRNP

door Vickers, Timothy A., Sabripour, Mahyar, Crooke, Stanley T.
Gepubliceerd in 2011

Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structures

door Shen, Wen, Liang, Xue-hai, Crooke, Stanley T.
Gepubliceerd in 2014

Clinical and Preclinical Pharmacokinetics and Pharmacodynamics of Mipomersen (Kynamro(®)): A Second-Generation Antisense Oligonucleotide Inhibitor of Apolipoprotein B

door Geary, Richard S., Baker, Brenda F., Crooke, Stanley T.
Gepubliceerd in Clin Pharmacokinet (2015)

Phosphorothioate modified oligonucleotide–protein interactions

door Crooke, Stanley T, Vickers, Timothy A, Liang, Xue-hai
Gepubliceerd in Nucleic Acids Res (2020)

Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages

door Liang, Xue-hai, Sun, Hong, Shen, Wen, Crooke, Stanley T.
Gepubliceerd in Nucleic Acids Res (2015)

2′-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF

door Shen, Wen, Liang, Xue-hai, Sun, Hong, Crooke, Stanley T.
Gepubliceerd in Nucleic Acids Res (2015)

Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides

door Wang, Shiyu, Allen, Nickolas, Liang, Xue-hai, Crooke, Stanley T.
Gepubliceerd in Mol Ther Nucleic Acids (2018)

Efficient and specific knockdown of small non-coding RNAs in mammalian cells and in mice

door Liang, Xue-hai, Vickers, Timothy A., Guo, Shuling, Crooke, Stanley T.
Gepubliceerd in 2011

RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus

door Liang, Xue-Hai, Sun, Hong, Nichols, Joshua G., Crooke, Stanley T.
Gepubliceerd in Mol Ther (2017)

Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides

door Bailey, Jeffrey K., Shen, Wen, Liang, Xue-hai, Crooke, Stanley T.
Gepubliceerd in Nucleic Acids Res (2017)

Translation can affect the antisense activity of RNase H1-dependent oligonucleotides targeting mRNAs

door Liang, Xue-Hai, Nichols, Joshua G, Sun, Hong, Crooke, Stanley T
Gepubliceerd in Nucleic Acids Res (2018)