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Translation can affect the antisense activity of RNase H1-dependent oligonucleotides targeting mRNAs

RNase H1-dependent antisense oligonucleotides (ASOs) can degrade complementary RNAs in both the nucleus and the cytoplasm. Since cytoplasmic mRNAs are actively engaged in translation, ASO activity may thus be affected by translating ribosomes that scan the mRNAs. Here we show that mRNAs associated w...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nucleic Acids Res
मुख्य लेखकों: Liang, Xue-Hai, Nichols, Joshua G, Sun, Hong, Crooke, Stanley T
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2018
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758896/
https://ncbi.nlm.nih.gov/pubmed/29165591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1174
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