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Translation can affect the antisense activity of RNase H1-dependent oligonucleotides targeting mRNAs
RNase H1-dependent antisense oligonucleotides (ASOs) can degrade complementary RNAs in both the nucleus and the cytoplasm. Since cytoplasmic mRNAs are actively engaged in translation, ASO activity may thus be affected by translating ribosomes that scan the mRNAs. Here we show that mRNAs associated w...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5758896/ https://ncbi.nlm.nih.gov/pubmed/29165591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1174 |
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