mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway

Antisense technology can reduce gene expression via the RNase H1 or RISC pathways and can increase gene expression through modulation of splicing or translation. Here, we demonstrate that antisense oligonucleotides (ASOs) can reduce mRNA levels by acting through the no-go decay pathway. Phosphorothi...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Liang, Xue-hai, Nichols, Joshua G, Hsu, Chih-Wei, Vickers, Timothy A, Crooke, Stanley T
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6649848/
https://ncbi.nlm.nih.gov/pubmed/31165876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz500
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