COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways

RNase H1-dependent, phosphorothioate-modified antisense oligonucleotides (PS-ASOs) can enter cells through endocytic pathways and need to be released from the membrane-enclosed organelles, a limiting step for antisense activity. Accumulating evidence has suggested that productive PS-ASO release main...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Liang, Xue-hai, Sun, Hong, Nichols, Joshua G, Allen, Nickolas, Wang, Shiyu, Vickers, Timothy A, Shen, Wen, Hsu, Chih-Wei, Crooke, Stanley T
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212795/
https://ncbi.nlm.nih.gov/pubmed/30239896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky841
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