Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides

Chemically modified antisense oligonucleotides with phosphorothioate linkages (PS-ASOs) mediate site-specific cleavage of RNA by RNase H1 and are broadly used as research and therapeutic tools. PS-ASOs can enter cells via endocytic pathways and escape from membrane-enclosed endocytic organelles to r...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: Wang, Shiyu, Allen, Nickolas, Liang, Xue-hai, Crooke, Stanley T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276310/
https://ncbi.nlm.nih.gov/pubmed/30508785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.10.011
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