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Annexin A2 facilitates endocytic trafficking of antisense oligonucleotides

Chemically modified antisense oligonucleotides (ASOs) designed to mediate site-specific cleavage of RNA by RNase H1 are used as research tools and as therapeutics. ASOs modified with phosphorothioate (PS) linkages enter cells via endocytotic pathways. The mechanisms by which PS-ASOs are released fro...

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書目詳細資料
發表在:Nucleic Acids Res
Main Authors: Wang, Shiyu, Sun, Hong, Tanowitz, Michael, Liang, Xue-hai, Crooke, Stanley T.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009748/
https://ncbi.nlm.nih.gov/pubmed/27378781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw595
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