Annexin A2 facilitates endocytic trafficking of antisense oligonucleotides

Chemically modified antisense oligonucleotides (ASOs) designed to mediate site-specific cleavage of RNA by RNase H1 are used as research tools and as therapeutics. ASOs modified with phosphorothioate (PS) linkages enter cells via endocytotic pathways. The mechanisms by which PS-ASOs are released fro...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Wang, Shiyu, Sun, Hong, Tanowitz, Michael, Liang, Xue-hai, Crooke, Stanley T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009748/
https://ncbi.nlm.nih.gov/pubmed/27378781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw595
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