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Annexin A2 facilitates endocytic trafficking of antisense oligonucleotides
Chemically modified antisense oligonucleotides (ASOs) designed to mediate site-specific cleavage of RNA by RNase H1 are used as research tools and as therapeutics. ASOs modified with phosphorothioate (PS) linkages enter cells via endocytotic pathways. The mechanisms by which PS-ASOs are released fro...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5009748/ https://ncbi.nlm.nih.gov/pubmed/27378781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw595 |
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