siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs

Por Vickers, Timothy A., Crooke, Stanley T.
Publicado em 2012

Antisense Oligonucleotides Capable of Promoting Specific Target mRNA Reduction via Competing RNase H1-Dependent and Independent Mechanisms

Por Vickers, Timothy A., Crooke, Stanley T.
Publicado em 2014

The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA

Por Vickers, Timothy A., Crooke, Stanley T.
Publicado no Nucleic Acids Res (2015)

Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein Interactions

Por Vickers, Timothy A., Crooke, Stanley T.
Publicado no PLoS One (2016)

U1 adaptors result in reduction of multiple pre-mRNA species principally by sequestering U1snRNP

Por Vickers, Timothy A., Sabripour, Mahyar, Crooke, Stanley T.
Publicado em 2011

The catalytic domain of RNase E shows inherent 3′ to 5′ directionality in cleavage site selection

Por Feng, Yanan, Vickers, Timothy A., Cohen, Stanley N.
Publicado em 2002

Effects of RNA secondary structure on cellular antisense activity

Por Vickers, Timothy A., Wyatt, Jacqueline R., Freier, Susan M.
Publicado em 2000

Efficient and specific knockdown of small non-coding RNAs in mammalian cells and in mice

Por Liang, Xue-hai, Vickers, Timothy A., Guo, Shuling, Crooke, Stanley T.
Publicado em 2011

Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells

Por Vickers, Timothy A., Lima, Walt F., Nichols, Josh G., Crooke, Stanley T.
Publicado em 2007

Defining the Factors That Contribute to On-Target Specificity of Antisense Oligonucleotides

Por Lima, Walt F., Vickers, Timothy A., Nichols, Josh, Li, Cheryl, Crooke, Stanley T.
Publicado em 2014

Targeting of Repeated Sequences Unique to a Gene Results in Significant Increases in Antisense Oligonucleotide Potency

Por Vickers, Timothy A., Freier, Susan M., Bui, Huynh-Hoa, Watt, Andrew, Crooke, Stanley T.
Publicado em 2014

Fully modified 2′ MOE oligonucleotides redirect polyadenylation

Por Vickers, Timothy A., Wyatt, Jacqueline R., Burckin, Todd, Bennett, C. Frank, Freier, Susan M.
Publicado em 2001

Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon

Por Hua, Yimin, Vickers, Timothy A, Baker, Brenda F, Bennett, C. Frank, Krainer, Adrian R
Publicado em 2007

Antisense Masking of an hnRNP A1/A2 Intronic Splicing Silencer Corrects SMN2 Splicing in Transgenic Mice

Por Hua, Yimin, Vickers, Timothy A., Okunola, Hazeem L., Bennett, C. Frank, Krainer, Adrian R.
Publicado em 2008

Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 ‘Slicer’ independent and can be mediated by Ago1

Por Vickers, Timothy A., Lima, Walt F., Wu, Hongjiang, Nichols, Josh G., Linsley, Peter S., Crooke, Stanley T.
Publicado em 2009

Modulation of LMNA splicing as a strategy to treat prelamin A diseases

Por Lee, John M., Nobumori, Chika, Tu, Yiping, Choi, Catherine, Yang, Shao H., Jung, Hea-Jin, Vickers, Timothy A., Rigo, Frank, Bennett, C. Frank, Young, Stephen G., Fong, Loren G.
Publicado no J Clin Invest (2016)

Activating the synthesis of progerin, the mutant prelamin A in Hutchinson–Gilford progeria syndrome, with antisense oligonucleotides

Por Fong, Loren G., Vickers, Timothy A., Farber, Emily A., Choi, Christine, Yun, Ui Jeong, Hu, Yan, Yang, Shao H., Coffinier, Catherine, Lee, Roger, Yin, Liya, Davies, Brandon S.J., Andres, Douglas A., Spielmann, H. Peter, Bennett, C. Frank, Young, Stephen G.
Publicado em 2009

Prelamin A and lamin A appear to be dispensable in the nuclear lamina

Por Fong, Loren G., Ng, Jennifer K., Lammerding, Jan, Vickers, Timothy A., Meta, Margarita, Coté, Nathan, Gavino, Bryant, Qiao, Xin, Chang, Sandy Y., Young, Stephanie R., Yang, Shao H., Stewart, Colin L., Lee, Richard T., Bennett, C. Frank, Bergo, Martin O., Young, Stephen G.
Publicado em 2006

Peptide Nucleic Acids Conjugated to Short Basic Peptides Show Improved Pharmacokinetics and Antisense Activity in Adipose Tissue

Por Wancewicz, Edward V., Maier, Martin A., Siwkowski, Andrew M., Albertshofer, Klaus, Winger, Theodore M., Berdeja, Andres, Gaus, Hans, Vickers, Timothy A., Bennett, C. Frank, Monia, Brett P., Griffey, Richard H., Nulf, Christopher J., Hu, Jiaxin, Corey, David R., Swayze, Eric E., Kinberger, Garth A.
Publicado em 2010