Activating the synthesis of progerin, the mutant prelamin A in Hutchinson–Gilford progeria syndrome, with antisense oligonucleotides

Hutchinson–Gilford progeria syndrome (HGPS) is caused by point mutations that increase utilization of an alternate splice donor site in exon 11 of LMNA (the gene encoding lamin C and prelamin A). The alternate splicing reduces transcripts for wild-type prelamin A and increases transcripts for a trun...

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Detalhes bibliográficos
Main Authors: Fong, Loren G., Vickers, Timothy A., Farber, Emily A., Choi, Christine, Yun, Ui Jeong, Hu, Yan, Yang, Shao H., Coffinier, Catherine, Lee, Roger, Yin, Liya, Davies, Brandon S.J., Andres, Douglas A., Spielmann, H. Peter, Bennett, C. Frank, Young, Stephen G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694694/
https://ncbi.nlm.nih.gov/pubmed/19376814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp184
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