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Increasing the length of progerin’s isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the synthesis of a truncated prelamin A, commonly called progerin, that contains a carboxyl-terminal farnesyl lipid anchor. The farnesyl lipid anchor helps to target progerin to membrane surfaces at the nuclear rim, where it disrupts the integ...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3837462/ https://ncbi.nlm.nih.gov/pubmed/18757838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800424-JLR200 |
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