Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria

Hutchinson-Gilford progeria (HGPS) is a premature ageing syndrome caused by a mutation in LMNA, resulting in a truncated form of lamin A called progerin. Progerin triggers loss of the heterochromatic marker H3K27me3, and premature senescence, which is prevented by telomerase. However, the mechanism...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Chojnowski, Alexandre, Ong, Peh Fern, Wong, Esther SM, Lim, John SY, Mutalif, Rafidah A, Navasankari, Raju, Dutta, Bamaprasad, Yang, Henry, Liow, Yi Y, Sze, Siu K, Boudier, Thomas, Wright, Graham D, Colman, Alan, Burke, Brian, Stewart, Colin L, Dreesen, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565980/
https://ncbi.nlm.nih.gov/pubmed/26312502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07759
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados