Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria

Hutchinson-Gilford progeria (HGPS) is a premature ageing syndrome caused by a mutation in LMNA, resulting in a truncated form of lamin A called progerin. Progerin triggers loss of the heterochromatic marker H3K27me3, and premature senescence, which is prevented by telomerase. However, the mechanism...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Chojnowski, Alexandre, Ong, Peh Fern, Wong, Esther SM, Lim, John SY, Mutalif, Rafidah A, Navasankari, Raju, Dutta, Bamaprasad, Yang, Henry, Liow, Yi Y, Sze, Siu K, Boudier, Thomas, Wright, Graham D, Colman, Alan, Burke, Brian, Stewart, Colin L, Dreesen, Oliver
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2015
Onderwerpen:
Genes and Chromosomes
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565980/
https://ncbi.nlm.nih.gov/pubmed/26312502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07759
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