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Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria
Hutchinson-Gilford progeria (HGPS) is a premature ageing syndrome caused by a mutation in LMNA, resulting in a truncated form of lamin A called progerin. Progerin triggers loss of the heterochromatic marker H3K27me3, and premature senescence, which is prevented by telomerase. However, the mechanism...
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| Gepubliceerd in: | eLife |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
eLife Sciences Publications, Ltd
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4565980/ https://ncbi.nlm.nih.gov/pubmed/26312502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07759 |
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