Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria

Hutchinson-Gilford progeria (HGPS) is a premature ageing syndrome caused by a mutation in LMNA, resulting in a truncated form of lamin A called progerin. Progerin triggers loss of the heterochromatic marker H3K27me3, and premature senescence, which is prevented by telomerase. However, the mechanism...

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Bibliographic Details
Published in:eLife
Main Authors: Chojnowski, Alexandre, Ong, Peh Fern, Wong, Esther SM, Lim, John SY, Mutalif, Rafidah A, Navasankari, Raju, Dutta, Bamaprasad, Yang, Henry, Liow, Yi Y, Sze, Siu K, Boudier, Thomas, Wright, Graham D, Colman, Alan, Burke, Brian, Stewart, Colin L, Dreesen, Oliver
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2015
Subjects:
Genes and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565980/
https://ncbi.nlm.nih.gov/pubmed/26312502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07759
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