Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria

Hutchinson-Gilford progeria (HGPS) is a premature ageing syndrome caused by a mutation in LMNA, resulting in a truncated form of lamin A called progerin. Progerin triggers loss of the heterochromatic marker H3K27me3, and premature senescence, which is prevented by telomerase. However, the mechanism...

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Publicado en:eLife
Autores principales: Chojnowski, Alexandre, Ong, Peh Fern, Wong, Esther SM, Lim, John SY, Mutalif, Rafidah A, Navasankari, Raju, Dutta, Bamaprasad, Yang, Henry, Liow, Yi Y, Sze, Siu K, Boudier, Thomas, Wright, Graham D, Colman, Alan, Burke, Brian, Stewart, Colin L, Dreesen, Oliver
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Genes and Chromosomes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565980/
https://ncbi.nlm.nih.gov/pubmed/26312502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07759
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