Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder that is characterized by dramatic premature aging and accelerated cardiovascular disease. HGPS is almost always caused by a de novo point mutation in the lamin A gene (LMNA) that activates a cryptic splice donor site, producing a...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Capell, Brian C., Erdos, Michael R., Madigan, James P., Fiordalisi, James J., Varga, Renee, Conneely, Karen N., Gordon, Leslie B., Der, Channing J., Cox, Adrienne D., Collins, Francis S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2005
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1200293/
https://ncbi.nlm.nih.gov/pubmed/16129833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506001102
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares