Treatment with a Farnesyltransferase Inhibitor Improves Survival in Mice with a Hutchinson-Gilford Progeria Syndrome Mutation

por Yang, Shao H., Qiao, Xin, Fong, Loren G., Young, Stephen G.
Publicado 2007

The posttranslational processing of prelamin A and disease

por Davies, Brandon S. J., Fong, Loren G., Yang, Shao H., Coffinier, Catherine, Young, Stephen G.
Publicado 2009

Are B-type lamins essential in all mammalian cells?

por Yang, Shao H., Jung, Hea-Jin, Coffinier, Catherine, Fong, Loren G., Young, Stephen G.
Publicado 2011

Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated

por Yang, Shao H., Andres, Douglas A., Spielmann, H. Peter, Young, Stephen G., Fong, Loren G.
Publicado 2008

Nuclear lamins in the brain—new insights into function and regulation

por Jung, Hea-Jin, Lee, John M., Yang, Shao H., Young, Stephen G., Fong, Loren G.
Publicado 2012

Targeting Protein Prenylation in Progeria

por Young, Stephen G., Yang, Shao H., Davies, Brandon S. J., Jung, Hea-Jin, Fong, Loren G.
Publicado 2013

Caution! Analyze transcripts from conditional knockout alleles

por Yang, Shao H., Bergo, Martin O., Farber, Emily, Qiao, Xin, Fong, Loren G., Young, Stephen G.
Publicado 2008

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

por Yang, Shao H., Chang, Sandy Y., Andres, Douglas A., Spielmann, H. Peter, Young, Stephen G., Fong, Loren G.
Publicado 2010

Investigating the purpose of prelamin A processing

por Davies, Brandon SJ, Coffinier, Catherine, Yang, Shao H, Barnes, Richard H, Jung, Hea-Jin, Young, Stephen G, Fong, Loren G
Publicado 2011

Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases

por Yang, Shao H., Chang, Sandy Y., Tu, Yiping, Lawson, Gregory W., Bergo, Martin O., Fong, Loren G., Young, Stephen G.
Publicado 2012

New Lmna knock-in mice provide a molecular mechanism for the ‘segmental aging’ in Hutchinson–Gilford progeria syndrome(†)

por Jung, Hea-Jin, Tu, Yiping, Yang, Shao H., Tatar, Angelica, Nobumori, Chika, Wu, Daniel, Young, Stephen G., Fong, Loren G.
Publicado 2014

Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin

por Yang, Shao H., Chang, Sandy Y., Ren, Shuxun, Wang, Yibin, Andres, Douglas A., Spielmann, H. Peter, Fong, Loren G., Young, Stephen G.
Publicado 2011

An Absence of Nuclear Lamins in Keratinocytes Leads to Ichthyosis, Defective Epidermal Barrier Function, and Intrusion of Nuclear Membranes and Endoplasmic Reticulum into the Nucle...

por Jung, Hea-Jin, Tatar, Angelica, Tu, Yiping, Nobumori, Chika, Yang, Shao H., Goulbourne, Chris N., Herrmann, Harald, Fong, Loren G., Young, Stephen G.
Publicado en Mol Cell Biol (2014)

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation

por Yang, Shao H., Meta, Margarita, Qiao, Xin, Frost, David, Bauch, Joy, Coffinier, Catherine, Majumdar, Sharmila, Bergo, Martin O., Young, Stephen G., Fong, Loren G.
Publicado 2006

An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair

por Yang, Shao H., Chang, Sandy Y., Yin, Liya, Tu, Yiping, Hu, Yan, Yoshinaga, Yuko, de Jong, Pieter J., Fong, Loren G., Young, Stephen G.
Publicado 2011

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

por Toth, Julia I., Yang, Shao H., Qiao, Xin, Beigneux, Anne P., Gelb, Michael H., Moulson, Casey L., Miner, Jeffrey H., Young, Stephen G., Fong, Loren G.
Publicado 2005

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson–Gilford progeria syndrome mutation

por Yang, Shao H., Bergo, Martin O., Toth, Julia I., Qiao, Xin, Hu, Yan, Sandoval, Salemiz, Meta, Margarita, Bendale, Pravin, Gelb, Michael H., Young, Stephen G., Fong, Loren G.
Publicado 2005

Modulation of LMNA splicing as a strategy to treat prelamin A diseases

por Lee, John M., Nobumori, Chika, Tu, Yiping, Choi, Catherine, Yang, Shao H., Jung, Hea-Jin, Vickers, Timothy A., Rigo, Frank, Bennett, C. Frank, Young, Stephen G., Fong, Loren G.
Publicado en J Clin Invest (2016)

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

por Fong, Loren G., Ng, Jennifer K., Meta, Margarita, Coté, Nathan, Yang, Shao H., Stewart, Colin L., Sullivan, Terry, Burghardt, Andrew, Majumdar, Sharmila, Reue, Karen, Bergo, Martin O., Young, Stephen G.
Publicado 2004

Increasing the length of progerin’s isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome

por Davies, Brandon S. J., Yang, Shao H., Farber, Emily, Lee, Roger, Buck, Suzanne B., Andres, Douglas A., Spielmann, H. Peter, Agnew, Brian J., Tamanoi, Fuyuhiko, Fong, Loren G., Young, Stephen G.
Publicado 2009