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Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases

Protein farnesyltransferase (FTase) and protein geranylgeranyltransferase-I (GGTase-I) add 15- or 20-carbon lipids, respectively, to proteins that terminate with a CaaX motif. These posttranslational modifications of proteins with lipids promote protein interactions with membrane surfaces in cells,...

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Bibliografiske detaljer
Main Authors: Yang, Shao H., Chang, Sandy Y., Tu, Yiping, Lawson, Gregory W., Bergo, Martin O., Fong, Loren G., Young, Stephen G.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243483/
https://ncbi.nlm.nih.gov/pubmed/22039581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M021220
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