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Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases
Protein farnesyltransferase (FTase) and protein geranylgeranyltransferase-I (GGTase-I) add 15- or 20-carbon lipids, respectively, to proteins that terminate with a CaaX motif. These posttranslational modifications of proteins with lipids promote protein interactions with membrane surfaces in cells,...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3243483/ https://ncbi.nlm.nih.gov/pubmed/22039581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M021220 |
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