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An Absence of Nuclear Lamins in Keratinocytes Leads to Ichthyosis, Defective Epidermal Barrier Function, and Intrusion of Nuclear Membranes and Endoplasmic Reticulum into the Nuclear Chromatin

B-type lamins (lamins B1 and B2) have been considered to be essential for many crucial functions in the cell nucleus (e.g., DNA replication and mitotic spindle formation). However, this view has been challenged by the observation that an absence of both B-type lamins in keratinocytes had no effect o...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: Jung, Hea-Jin, Tatar, Angelica, Tu, Yiping, Nobumori, Chika, Yang, Shao H., Goulbourne, Chris N., Herrmann, Harald, Fong, Loren G., Young, Stephen G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248738/
https://ncbi.nlm.nih.gov/pubmed/25312645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00997-14
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