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Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin
Hutchinson–Gilford progeria syndrome (HGPS) is caused by a mutant prelamin A, progerin, that terminates with a farnesylcysteine. HGPS knock-in mice (Lmna(HG/+)) develop severe progeria-like disease phenotypes. These phenotypes can be ameliorated with a protein farnesyltransferase inhibitor (FTI), su...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3016906/ https://ncbi.nlm.nih.gov/pubmed/21088111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq490 |
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