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Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the accumulation of a farnesylated form of prelamin A (progerin). Previously, we showed that blocking protein farnesylation with a farnesyltransferase inhibitor (FTI) ameliorates the disease phenotypes in mouse model of HGPS (Lmna(HG/+)). Howe...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2803242/ https://ncbi.nlm.nih.gov/pubmed/19965595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M002808 |
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