Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

Hutchinson-Gilford progeria syndrome (HGPS) is caused by the accumulation of a farnesylated form of prelamin A (progerin). Previously, we showed that blocking protein farnesylation with a farnesyltransferase inhibitor (FTI) ameliorates the disease phenotypes in mouse model of HGPS (Lmna(HG/+)). Howe...

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Autores principales: Yang, Shao H., Chang, Sandy Y., Andres, Douglas A., Spielmann, H. Peter, Young, Stephen G., Fong, Loren G.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803242/
https://ncbi.nlm.nih.gov/pubmed/19965595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M002808
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