A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation

Hutchinson-Gilford progeria syndrome (HGPS) is caused by the production of a truncated prelamin A, called progerin, which is farnesylated at its carboxyl terminus. Progerin is targeted to the nuclear envelope and causes misshapen nuclei. Protein farnesyltransferase inhibitors (FTI) mislocalize proge...

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Bibliografische gegevens
Hoofdauteurs: Yang, Shao H., Meta, Margarita, Qiao, Xin, Frost, David, Bauch, Joy, Coffinier, Catherine, Majumdar, Sharmila, Bergo, Martin O., Young, Stephen G., Fong, Loren G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2006
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1513052/
https://ncbi.nlm.nih.gov/pubmed/16862216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28968
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