Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson–Gilford progeria syndrome mutation

Hutchinson–Gilford progeria syndrome (HGPS), a progeroid syndrome in children, is caused by mutations in LMNA (the gene for prelamin A and lamin C) that result in the deletion of 50 aa within prelamin A. In normal cells, prelamin A is a “CAAX protein” that is farnesylated and then processed further...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Yang, Shao H., Bergo, Martin O., Toth, Julia I., Qiao, Xin, Hu, Yan, Sandoval, Salemiz, Meta, Margarita, Bendale, Pravin, Gelb, Michael H., Young, Stephen G., Fong, Loren G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1174929/
https://ncbi.nlm.nih.gov/pubmed/16014412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504641102
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados