Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson–Gilford progeria syndrome

Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare, fatal, segmental premature aging syndrome caused by a mutation in LMNA that produces the farnesylated aberrant lamin A protein, progerin. This multisystem disorder causes failure to thrive and accelerated atherosclerosis leading to ea...

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Bibliografische gegevens
Hoofdauteurs: Gordon, Leslie B., Kleinman, Monica E., Miller, David T., Neuberg, Donna S., Giobbie-Hurder, Anita, Gerhard-Herman, Marie, Smoot, Leslie B., Gordon, Catherine M., Cleveland, Robert, Snyder, Brian D., Fligor, Brian, Bishop, W. Robert, Statkevich, Paul, Regen, Amy, Sonis, Andrew, Riley, Susan, Ploski, Christine, Correia, Annette, Quinn, Nicolle, Ullrich, Nicole J., Nazarian, Ara, Liang, Marilyn G., Huh, Susanna Y., Schwartzman, Armin, Kieran, Mark W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2012
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478615/
https://ncbi.nlm.nih.gov/pubmed/23012407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202529109
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