Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson–Gilford progeria syndrome

Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare, fatal, segmental premature aging syndrome caused by a mutation in LMNA that produces the farnesylated aberrant lamin A protein, progerin. This multisystem disorder causes failure to thrive and accelerated atherosclerosis leading to ea...

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Bibliografiset tiedot
Päätekijät: Gordon, Leslie B., Kleinman, Monica E., Miller, David T., Neuberg, Donna S., Giobbie-Hurder, Anita, Gerhard-Herman, Marie, Smoot, Leslie B., Gordon, Catherine M., Cleveland, Robert, Snyder, Brian D., Fligor, Brian, Bishop, W. Robert, Statkevich, Paul, Regen, Amy, Sonis, Andrew, Riley, Susan, Ploski, Christine, Correia, Annette, Quinn, Nicolle, Ullrich, Nicole J., Nazarian, Ara, Liang, Marilyn G., Huh, Susanna Y., Schwartzman, Armin, Kieran, Mark W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2012
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478615/
https://ncbi.nlm.nih.gov/pubmed/23012407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202529109
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