An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria

Lamin A is formed from prelamin A by four post-translational processing steps—farnesylation, release of the last three amino acids of the protein, methylation of the farnesylcysteine and the endoproteolytic release of the C-terminal 15 amino acids (including the farnesylcysteine methyl ester). When...

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Bibliographic Details
Main Authors: Davies, Brandon S.J., Barnes, Richard H., Tu, Yiping, Ren, Shuxun, Andres, Douglas A., Spielmann, H. Peter, Lammerding, Jan, Wang, Yibin, Young, Stephen G., Fong, Loren G.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883346/
https://ncbi.nlm.nih.gov/pubmed/20421363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq158
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