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An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria
Lamin A is formed from prelamin A by four post-translational processing steps—farnesylation, release of the last three amino acids of the protein, methylation of the farnesylcysteine and the endoproteolytic release of the C-terminal 15 amino acids (including the farnesylcysteine methyl ester). When...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2883346/ https://ncbi.nlm.nih.gov/pubmed/20421363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq158 |
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