A Potent HIV Protease Inhibitor, Darunavir, Does Not Inhibit ZMPSTE24 or Lead to an Accumulation of Farnesyl-prelamin A in Cells

HIV protease inhibitors (HIV-PIs) are key components of highly active antiretroviral therapy, but they have been associated with adverse side effects, including partial lipodystrophy and metabolic syndrome. We recently demonstrated that a commonly used HIV-PI, lopinavir, inhibits ZMPSTE24, thereby b...

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Auteurs principaux: Coffinier, Catherine, Hudon, Sarah E., Lee, Roger, Farber, Emily A., Nobumori, Chika, Miner, Jeffrey H., Andres, Douglas A., Spielmann, H. Peter, Hrycyna, Christine A., Fong, Loren G., Young, Stephen G.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2008
Sujets:
Protein Synthesis, Post-Translational Modification, and Degradation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442292/
https://ncbi.nlm.nih.gov/pubmed/18230615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709629200
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