Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24

Protein farnesyltransferase (FTase) inhibitors, generally called “FTIs,” block the farnesylation of prelamin A, inhibiting the biogenesis of mature lamin A and leading to an accumulation of prelamin A within cells. A recent report found that a GGTI, an inhibitor of protein geranylgeranyltransferase-...

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Detalhes bibliográficos
Main Authors: Chang, Sandy Y., Hudon-Miller, Sarah E., Yang, Shao H., Jung, Hea-Jin, Lee, John M., Farber, Emily, Subramanian, Thangaiah, Andres, Douglas A., Spielmann, H. Peter, Hrycyna, Christine A., Young, Stephen G., Fong, Loren G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351824/
https://ncbi.nlm.nih.gov/pubmed/22448028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M026161
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