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HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells

HIV protease inhibitors (HIV-PIs) target the HIV aspartyl protease, which cleaves the HIV gag-pol polyprotein into shorter proteins required for the production of new virions. HIV-PIs are a cornerstone of treatment for HIV but have been associated with lipodystrophy and other side effects. In both h...

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Detalhes bibliográficos
Main Authors: Coffinier, Catherine, Hudon, Sarah E., Farber, Emily A., Chang, Sandy Y., Hrycyna, Christine A., Young, Stephen G., Fong, Loren G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948915/
https://ncbi.nlm.nih.gov/pubmed/17652517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704212104
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