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Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24
The integral membrane zinc metalloprotease ZMPSTE24 is important for human health and longevity. ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the farnesylated precursor of the nuclear scaffold protein lamin A. Mutations in the genes encoding either prelamin A or ZMPSTE24 tha...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7948416/ https://ncbi.nlm.nih.gov/pubmed/33293369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015792 |
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