Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24

The integral membrane zinc metalloprotease ZMPSTE24 is important for human health and longevity. ZMPSTE24 performs a key proteolytic step in maturation of prelamin A, the farnesylated precursor of the nuclear scaffold protein lamin A. Mutations in the genes encoding either prelamin A or ZMPSTE24 tha...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Babatz, Timothy D., Spear, Eric D., Xu, Wenxin, Sun, Olivia L., Nie, Laiyin, Carpenter, Elisabeth P., Michaelis, Susan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948416/
https://ncbi.nlm.nih.gov/pubmed/33293369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015792
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