Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24

The integral membrane zinc metalloprotease ZMPSTE24 plays a key role in the proteolytic processing of farnesylated prelamin A, the precursor of the nuclear scaffold protein lamin A. Failure of this processing step results in the accumulation of permanently farnesylated forms of prelamin A which caus...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Wood, Kaitlin M., Spear, Eric D., Mossberg, Otto W., Odinammadu, Kamsi O., Xu, Wenxin, Michaelis, Susan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735620/
https://ncbi.nlm.nih.gov/pubmed/33315887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239269
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