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Requirements for Efficient Proteolytic Cleavage of Prelamin A by ZMPSTE24

BACKGROUND: The proteolytic maturation of the nuclear protein lamin A by the zinc metalloprotease ZMPSTE24 is critical for human health. The lamin A precursor, prelamin A, undergoes a multi-step maturation process that includes CAAX processing (farnesylation, proteolysis and carboxylmethylation of t...

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書誌詳細
主要な著者: Barrowman, Jemima, Hamblet, Corinne, Kane, Megan S., Michaelis, Susan
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280227/
https://ncbi.nlm.nih.gov/pubmed/22355414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032120
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