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Requirements for Efficient Proteolytic Cleavage of Prelamin A by ZMPSTE24
BACKGROUND: The proteolytic maturation of the nuclear protein lamin A by the zinc metalloprotease ZMPSTE24 is critical for human health. The lamin A precursor, prelamin A, undergoes a multi-step maturation process that includes CAAX processing (farnesylation, proteolysis and carboxylmethylation of t...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3280227/ https://ncbi.nlm.nih.gov/pubmed/22355414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032120 |
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