Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores

Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and exerts toxicity, causing a variety of disease phenotypes. By ∼4 month...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Heizer, Patrick J., Yang, Ye, Tu, Yiping, Kim, Paul H., Chen, Natalie Y., Hu, Yan, Yoshinaga, Yuko, de Jong, Pieter J., Vergnes, Laurent, Morales, Jazmin E., Li, Robert L., Jackson, Nicholas, Reue, Karen, Young, Stephen G., Fong, Loren G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053845/
https://ncbi.nlm.nih.gov/pubmed/31941672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000593
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