Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores

Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and exerts toxicity, causing a variety of disease phenotypes. By ∼4 month...

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Dettagli Bibliografici
Pubblicato in:J Lipid Res
Autori principali: Heizer, Patrick J., Yang, Ye, Tu, Yiping, Kim, Paul H., Chen, Natalie Y., Hu, Yan, Yoshinaga, Yuko, de Jong, Pieter J., Vergnes, Laurent, Morales, Jazmin E., Li, Robert L., Jackson, Nicholas, Reue, Karen, Young, Stephen G., Fong, Loren G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053845/
https://ncbi.nlm.nih.gov/pubmed/31941672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000593
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