Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores

Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and exerts toxicity, causing a variety of disease phenotypes. By ∼4 month...

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Bibliografiska uppgifter
I publikationen:J Lipid Res
Huvudupphovsmän: Heizer, Patrick J., Yang, Ye, Tu, Yiping, Kim, Paul H., Chen, Natalie Y., Hu, Yan, Yoshinaga, Yuko, de Jong, Pieter J., Vergnes, Laurent, Morales, Jazmin E., Li, Robert L., Jackson, Nicholas, Reue, Karen, Young, Stephen G., Fong, Loren G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Biochemistry and Molecular Biology 2020
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053845/
https://ncbi.nlm.nih.gov/pubmed/31941672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000593
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