Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores

Zinc metallopeptidase STE24 (ZMPSTE24) is essential for the conversion of farnesyl–prelamin A to mature lamin A, a key component of the nuclear lamina. In the absence of ZMPSTE24, farnesyl–prelamin A accumulates in the nucleus and exerts toxicity, causing a variety of disease phenotypes. By ∼4 month...

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Dades bibliogràfiques
Publicat a:J Lipid Res
Autors principals: Heizer, Patrick J., Yang, Ye, Tu, Yiping, Kim, Paul H., Chen, Natalie Y., Hu, Yan, Yoshinaga, Yuko, de Jong, Pieter J., Vergnes, Laurent, Morales, Jazmin E., Li, Robert L., Jackson, Nicholas, Reue, Karen, Young, Stephen G., Fong, Loren G.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053845/
https://ncbi.nlm.nih.gov/pubmed/31941672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000593
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