Mice that express farnesylated versions of prelamin A in neurons develop achalasia

Neurons in the brain produce lamin C but almost no lamin A, a consequence of the removal of prelamin A transcripts by miR-9, a brain-specific microRNA. We have proposed that miR-9-mediated regulation of prelamin A in the brain could explain the absence of primary neurological disease in Hutchinson-G...

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Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Yang, Shao H., Procaccia, Shiri, Jung, Hea-Jin, Nobumori, Chika, Tatar, Angelica, Tu, Yiping, Bayguinov, Yulia R., Hwang, Sung Jin, Tran, Deanna, Ward, Sean M., Fong, Loren G., Young, Stephen G.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406294/
https://ncbi.nlm.nih.gov/pubmed/25652409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv043
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