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Mice that express farnesylated versions of prelamin A in neurons develop achalasia
Neurons in the brain produce lamin C but almost no lamin A, a consequence of the removal of prelamin A transcripts by miR-9, a brain-specific microRNA. We have proposed that miR-9-mediated regulation of prelamin A in the brain could explain the absence of primary neurological disease in Hutchinson-G...
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| Published in: | Hum Mol Genet |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4406294/ https://ncbi.nlm.nih.gov/pubmed/25652409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv043 |
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