Modulation of LMNA splicing as a strategy to treat prelamin A diseases

The alternatively spliced products of LMNA, lamin C and prelamin A (the precursor to lamin A), are produced in similar amounts in most tissues and have largely redundant functions. This redundancy suggests that diseases, such as Hutchinson-Gilford progeria syndrome (HGPS), that are caused by prelami...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Lee, John M., Nobumori, Chika, Tu, Yiping, Choi, Catherine, Yang, Shao H., Jung, Hea-Jin, Vickers, Timothy A., Rigo, Frank, Bennett, C. Frank, Young, Stephen G., Fong, Loren G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811112/
https://ncbi.nlm.nih.gov/pubmed/26999604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85908
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