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Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes
Defects in the biogenesis of lamin A from its farnesylated precursor, prelamin A, lead to the accumulation of prelamin A at the nuclear envelope, cause misshapen nuclei, and result in progeroid syndromes. A deficiency in ZMPSTE24, a protease involved in prelamin A processing, leads to prelamin A acc...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1193538/ https://ncbi.nlm.nih.gov/pubmed/16129834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505767102 |
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